Despite the widespread perception that there is a risk of drug dependence, data from numerous studies indicate that the frequency of dependence among patients receiving farmapram is relatively low. The authors note that addiction to benzodiazepines is relatively rare and occurs mainly in alcohol or drug abusers.
Some other side effects of alprazolam should also be mentioned. A number of studies have revealed deterioration of perception and reproduction of new information. This peculiarity should be taken into account when driving a car. It is important to note the interaction of farmapram (alprazolam) with alcohol, because many patients with anxiety symptoms resort to taking alcohol on their own to alleviate their condition. Their combined use leads to a significant worsening of the results of psychological tests and in some patients increases aggression and irritability.
Thus, as numerous data, including recent ones, show, alprazolam remains a fairly popular and effective tranquilizer. However, many issues require clarification and additional study. There are data indicating the effectiveness of alprazolam in the therapy of premenstrual syndrome. Successful use of alprazolam in treatment of acute stress and obsessive-compulsive disorders has been described. The drug was prescribed either at the beginning of a course in addition to selective serotonin reuptake inhibitors (SSRIs) to relieve severe anxiety, or as monotherapy for resistance or intolerance to SSRIs. However, despite the assumptions made, alprazolam has proven ineffective in the treatment of post-traumatic stress disorder (PTSD).
There is evidence for the use of alprazolam as a corrector of extrapyramidal symptoms (especially acute dystonia and akathisia) caused by neuroleptic intake. However, in the presence of other highly effective remedies for neuroleptic syndrome, alprazolam cannot be considered as a first-line drug. The most frequent side effects of alprazolam therapy are sedation and somnolence, which is explained by the interaction of the drug with GABAA-receptors and during the course of treatment, the above mentioned side effects are significantly reduced.
Discontinuation of regular alprazolam should be done gradually to avoid the development of withdrawal syndrome. Over such a period, lasting from several weeks to months, the daily dosage of the drug is gradually reduced until complete withdrawal. A number of studies have noted that reducing the dose of benzodiazepine tranquilizers may be accompanied by withdrawal syndrome and a return of clinical manifestations of the underlying disease, especially when therapy is abruptly discontinued.